Combination of Epstein-Barr Virus-Based Plasmid and Nonviral Polymeric Vectors for Enhanced and Prolonged Gene Expression
نویسندگان
چکیده
Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 305-764, Korea Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, Korea *E-mail: [email protected] School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, Korea *E-mail: [email protected] Received July 17, 2012, Accepted August 14, 2012
منابع مشابه
Evaluation of Changes in NFKB Gene Expression Following Epstein-Barr Virus and its Participation in the Half-Life of Patients With Acute Epstein-Barr Positive Lymphoblastic Leukemia
Aim: Leukemia targets are one of the most common childhood malignancies. Epstein-Barr virus is a tumorigenic virus of the herpes family of viruses and causes primary infection in young children. The aim of this study was to evaluate the increase in NFKB expression following EBV virus and its contribution to the half-life of EBV-positive acute lymphoblastic leukemia patients. Materials and Meth...
متن کاملMolecular therapeutics of cancer by means of electroporation-based transfer of siRNAs and EBV-based expression vectors.
A variety of gene transfer technologies have been devised as tools for functional analysis of genes as well as gene therapy and regenerative medicine. Electroporation enables efficient genetic transfection in vivo into various organs as well as tumors without the aid of any infectious viral vector, and has been applied to preclinical nonviral gene therapy approaches. The efficacies of transfect...
متن کاملExpression of Epstein-Barr virus in Hodgkin lymphoma Specimens in IRAN.
Background & Objectives: The Epstein-Barr Virus (EBV( is related with various diseases including infectious mononucleosis, Burkitt's lymphoma, Hodgkin's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoprolifrative disorders. The aim of this study was to characterize the association between EBV and Hodgkin's lymphoma through EBERs in situ hybridization (EBER-ISH) in Iranian pat...
متن کاملStudy on the association of Epstein - Barr virus with breast cancer in Khorramabad breast cancer patients, Iran
Background: Breast cancer is one of the most common malignancies in the world, and early diagnosis of this cancer is a key factor in its treatment. This cancer is a multi-stage disease, in which viruses can play a role. EBV is known as an important factor in the development of some human cancers. Therefore, this study was conducted to determine the relationship between Epstein-Barr virus, EBV, ...
متن کاملExpression Cloning of Recombinant Escherichia coli lacZ Genes Encoding Cytoplasmic and Nuclear P-galactosidase Variants
Objective(s) Nonviral vector can be an attractive alternative to gene delivery in experimental study. In spite of some advantages in comparison with the viral vectors, there are still some limitations for efficiency of gene delivery in nonviral vectors. To determine the effective expression, the recombinant Escherichia coli lacZ genes were cloned into the different variants of pcDNA3.1 and the...
متن کامل